Expression of Mage Genes By Non-small-cell Lung Carcinomas

Weynants, Patrick;Lethé, Bernard;Brasseur, Francis;Marchand, Marie;Boon-Falleur, Thierry
(1994) International Journal of Cancer — Vol. 56, n° 6, p. 826-829 (1994)

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Authors
  • Weynants, PatrickUCLouvain
    Author
  • Lethé, BernardUCLouvain
    Author
  • Brasseur, FrancisUCLouvain
    Author
  • Marchand, MarieUCLouvain
    Author
  • Boon-Falleur, ThierryUCLouvain
    Author
Abstract
Human gene MAGE-1 codes for an antigen that is recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). This antigen is potentially useful as a target for cancer immunotherapy because gene MAGE-1 is not expressed in any normal tissues except the testis. We tested 46 surgical samples of non-small-cell lung carcinomas and observed MAGE-1 expression in 16 of them (35%). Genes MAGE-2 and 3, which are closely related to MAGE-1, were expressed by a similar proportion of these tumors. Some small-cell lung tumors also express MAGE genes. The proportion of tumors expressing MAGE-1 suggests that lung tumor patients may constitute the largest group of patients potentially eligible for pilot studies involving MAGE-1 immunization. (C) 1994 Wiley-Liss, Inc.
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Weynants, P., Lethé, B., Brasseur, F., Marchand, M., & Boon-Falleur, T. (1994). Expression of Mage Genes By Non-small-cell Lung Carcinomas. International Journal of Cancer, 56(6), 826-829. https://doi.org/10.1002/ijc.2910560612 (Original work published 1994)