The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention

Green, Michael;Squires, James E.;Chinnock, Richard E.;Comoli, Patrizia;Dharnidharka, Vikas R.;et.al.
(2024) Pediatric Transplantation — Vol. 28, n° 1, p. e14350 (2024)

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  • Green, Michaelorcid-logo
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  • Squires, James E.orcid-logo
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  • Chinnock, Richard E.
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  • Comoli, Patrizia
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  • Dharnidharka, Vikas R.orcid-logo
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Abstract
The International Pediatric Transplant Association (IPTA) convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post-transplant lymphoproliferative disorder after solid organ transplantation in children. In this report from the Prevention Working Group, we reviewed the existing literature regarding immunoprophylaxis and chemoprophylaxis, and pre-emptive strategies. While the group made a strong recommendation for pre-emptive reduction of immunosuppression at the time of EBV DNAemia (low to moderate evidence), no recommendations for use could be made for any prophylactic strategy or alternate pre-emptive strategy, largely due to insufficient or conflicting evidence. Current gaps and future research priorities are highlighted.
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Green, M., Squires, J. E., Chinnock, R. E., Comoli, P., Danziger‐Isakov, L., Dulek, D. E., Esquivel, C. O., Höcker, B., L’Huillier, A. G., Mazariegos, G. V., Visner, G. A., Bollard, C. M., Dipchand, A. I., Ferry, J. A., Gross, T. G., Hayashi, R., Maecker‐Kolhoff, B., Marks, S., Martinez, O. M., et al. (2024). The IPTA Nashville consensus conference on Post-Transplant lymphoproliferative disorders after solid organ transplantation in children: II-consensus guidelines for prevention. Pediatric Transplantation, 28(1), e14350. https://doi.org/10.1111/petr.14350 (Original work published 2024)