Association of the glucocorticoid hormone receptor with ribonucleic acid.
(1985) FEBS Letters — Vol. 181, n° 1, p. 47-52 (1985)
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- Abstract
- The hypothesis that the glucocorticoid hormone receptor interacts with RNA has been tested in cultured rat hepatoma cells. The receptor was covalently labeled with radioactive dexamethasone mesylate, and putative RNA-receptor complexes were stabilized by either cell-free crosslinking using formaldehyde or irradiation of intact cells. After chemical cross-linking in vitro, the receptor displayed the buoyant density of a ribonucleoprotein in CsCl gradients. After photochemical crosslinking in cells labeled with radioactive uridine, the receptor analysed by polyacrylamide gel electrophoresis was carrying labeled ribonucleotides.
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Economidis, I. V., & Rousseau, G. (1985). Association of the glucocorticoid hormone receptor with ribonucleic acid. FEBS Letters, 181(1), 47-52. https://doi.org/10.1016/0014-5793(85)81111-X (Original work published 1985)