Air-accelerated enantioselective hydrosilylation of ketones catalyzed by copper(I) fluoride-diphosphine complexes: Investigations of the effects of temperature and ligand structure

Mostefai, Naouël;Sirol, Sabine;Courmarcel, James;Riant, Olivier
(2007) Synthesis : journal of synthetic organic chemistry — n° 8, p. 1265-1271 (2007)

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  • Mostefai, NaouëlUCLouvain
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  • Sirol, Sabine
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  • Courmarcel, James
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  • Riant, OlivierUCLouvain
    Author
Abstract
The fluorotris(triphenylphosphine)copper(I)-bis(methanol) complex-chiral diphosphine system catalyzes the hydrosilylation of several alkyl aryl ketones with moderate to excellent enantioselectivity. An oxygen acceleration effect was observed and led to a practical protocol with low catalyst loading. Optimizations of enantioselectivities (< 95%) and catalytic ratio (< 0.05 mol%) were obtained with bulky Ar-MeO-BIPHEP ligands.
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Mostefai, N., Sirol, S., Courmarcel, J., & Riant, O. (2007). Air-accelerated enantioselective hydrosilylation of ketones catalyzed by copper(I) fluoride-diphosphine complexes: Investigations of the effects of temperature and ligand structure. Synthesis : journal of synthetic organic chemistry, 8, 1265-1271. https://doi.org/10.1055/s-2007-966000 (Original work published 2007)