Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity.

Nieuwland, Rienk;Gardiner, Chris;Dignat-George, Françoise;Mullier, François;Thaler, Johannes;et.al.
(2019) Journal of thrombosis and haemostasis — Vol. 17, n° 8, p. 1261-1264 (2019)

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Authors
  • Nieuwland, Rienk
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  • Gardiner, Chris
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  • Dignat-George, Françoise
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  • Thaler, Johannesorcid-logo
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Abstract
(en) The clinical and scientific interest in extracellular vesicles (EVs) is growing exponentially. The term EVs is an umbrella term for various types of vesicles that are present in body fluids and other (bio)fluids. This umbrella term is used because clear hallmarks to distinguish different types of EVs from each other are lacking. Thus, the term “EVs” encompasses earlier “microparticles” or “microvesicles” and exosomes, which are vesicles released directly from the plasma membrane or by secretion of intraluminal vesicles stored in multivesicular endosomes, respectively.1, 2 There is evidence that EVs play a role in intercellular communication and contribute to coagulation and likely inflammation [...]
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Citations

Nieuwland, R., Gardiner, C., Dignat-George, F., Mullier, F., Mackman, N., Woodhams, B., & Thaler, J. (2019). Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity. Journal of thrombosis and haemostasis, 17(8), 1261-1264. https://doi.org/10.1111/jth.14481 (Original work published 2019)