The role of intestinal microbiota in energy metabolism and metabolic discorders.
(2010) International Diabetes Monitor — Vol. 22, n° 5, p. 189-195 (2010)
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- Abstract
- Obesity and its associated metabolic disorders are a worldwide epidemic. In humans, obesity causes changes in gut microbial composition. Analysis of the consequences of these changes for host energy metabolism, particularly in the context of obesity, requires good experimental models. The use of gnotobiotic animal models has indicated new mediators and molecular targets that suggest a metabolic dialogue between the gut bacteria and the host. The discovery of the impact of a high-fat diet on metabolic disorders linked to gut microbiota has revealed bacterial components (lipopolysaccharides and Toll-like receptors) as potential targets in the management of obesity and related disorders. In animal models, it has been possible to effect specific changes to the gut microbiota through food components with prebiotic properties, thereby decreasing obesity and its associated metabolic alterations, including inflammation. The relevance of this approach in the management of obesity in humans is supported by a number of intervention studies. A metagenomic and integrative metabolomic approach could help in the discovery of which bacteria, among the trillions in the human gut, are specifically involved in the control of host energy metabolism. This knowledge could be relevant for future therapeutic developments in the prevention of obesity and related metabolic disorders.
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Delzenne, N., & Cani, P. (2010). The role of intestinal microbiota in energy metabolism and metabolic discorders. International Diabetes Monitor, 22(5), 189-195. https://hdl.handle.net/2078.5/159205 (Original work published 2010)