Formation of Four-Membered Heterocycles
(2025) Comprehensive Organic Synthesis,3rd Edition — ISBN: [9780080977430], published
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- This Chapter focuses on developments in [2 þ 2] cycloadditions leading to four-membered heterocycles (b-lactams, b-lactones, b-sultams, azetidines, .). Special attention is drawn to the mechanistic aspects of the reactions and their consequences on the stereochemical outcome of the cycloaddition processes. Accordingly, the subdivision in sections reflects this point of view: the entries are related to reactions of various reagents (ketenes, enolates, ynolates, isocyanates, etc.) with C1⁄4X bonds instead of a list of types of heterocycles. The emphasis is also put on asymmetric catalysis, which is of particular interest for the enantioselective synthesis of biologically active compounds or their precursors.
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Robiette, R. (2025). Formation of Four-Membered Heterocycles. In Knochel, Paul (ed.), Comprehensive Organic Synthesis,3rd Edition. Elsevier Ltd. https://doi.org/10.1016/B978-0-08-097742-3.00503-6