Neutrophil-to-lymphocyte ratio (NLR) distribution shows an advantage compared to C-reactive protein (CRP) for the early inflammation monitoring after total hip arthroplasty

Mundama, Meni;Van Cauter, Maïté;Detrembleur, Christine;Cornu, Olivier;Yombi, Jean Cyr;et.al.
(2020) Acta Orthopaedica Belgica (Bilingual Edition) — Vol. 86, n° 3, p. 405-411 (2020)

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Abstract
C-reactive protein (CRP) distribution has been used to monitor early inflammation after total hip arthroplasty (THA). Neutrophil to lymphocyte ratio (NLR) is a new and cheap inflammatory marker. This study aimed to verify whether Neutrophil to lymphocyte ratio (NLR) distribution has an advantage when compared to C-reactive protein (CRP) distribution for the inflammation monitoring after total hip arthroplasty (THA). 116 THA patients were retrospectively selected over a 2 years period. They all had available blood tests preoperatively and at postoperative days 2, 4 and 42. Median peak values were compared between CRP and NLR. The effect of demographics on CRP and NLR was tested. At days 4 and 42, 100% and 16.3% of patients had not reached normal CRP (< 10mg/L) while 56.8% and 6.8% of patients had not reached normal NLR (<5) respectively. There was no effect of demographics on NLR except for age. Older patients had higher NLR (p 0.037). NLR showed a quicker return to normal than CRP. Our results show that NLR seems to be a better marker to follow inflammation after THA than CRP.
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Mundama, M., Van Cauter, M., Detrembleur, C., Cornu, O., Dubuc, J.-E., & Yombi, J. C. (2020). Neutrophil-to-lymphocyte ratio (NLR) distribution shows an advantage compared to C-reactive protein (CRP) for the early inflammation monitoring after total hip arthroplasty. Acta Orthopaedica Belgica (Bilingual Edition), 86(3), 405-411. https://hdl.handle.net/2078.5/168121 (Original work published 2020)