Hypoxia and post-hepatectomy liver failure : a double-edged sword post-extended hepatectomy
(2025)
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Hypoxiaandpost-hepatectomyliverfailureadouble-edgedswordpostextendedhepatectomy-19-12-24-17x24bookedited-apresepreuve-DIAL.pdf
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- Abstract
- Liver resection is the only curative treatment for liver tumors but is associated with a significant risk of post-hepatectomy liver failure (PHLF), marked by high mortality. The lack of mechanistic understanding limits treatment options. Discrepancies exist about the role of tissue hypoxia after extended hepatectomy. Once considered as a key driver of PHLF pathophysiology, recent studies reported a protective effect of early hypoxia. In this study, we investigated how hypoxia modulates regeneration after PHLF-inducing hepatectomy. Our work reveals a timing-dependent role of hypoxia in liver regeneration. While early hypoxia prevents vascular damage, stimulates vasculogenesis, preserves liver architecture, and promotes hepatocyte function, prolonged hypoxia causes hepatocyte cell cycle arrest and hinders recovery, reversible upon oxygenation of the liver remnant. Our findings identify hypoxia as a critical modulator of liver regeneration after extended hepatectomy.
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Citations
De Rudder, M. (2025). Hypoxia and post-hepatectomy liver failure : a double-edged sword post-extended hepatectomy. https://hdl.handle.net/2078.5/238908