Remission of infantile generalized myofibromatosis after interferon alpha therapy.
(2008) Journal of Pediatric Hematology / Oncology — Vol. 30, n° 2, p. 179-181 (2008)
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- Authors
- Abstract
- Infantile myofibromatosis is the most common fibrous tumor of infancy. Solitary or generalized myofibromas without visceral involvement usually regress within a few months. The multifocal disease infantile generalized myofibromatosis, with visceral involvement, is associated with a significant mortality due to the effect of tumors on vital organs. We report a case of infantile generalized myofibromatosis with visceral involvement, including 2 right atrium tumors. The infant expressed high circulating vascular endothelial growth factor and fibroblast growth factor-2 levels, and interferon alpha-2b was started as antiangiogenic treatment, aimed at triggering regression of the life-threatening cardiac lesions. The tumors regressed and vascular endothelial growth factor and fibroblast growth factor-2 levels were reduced after treatment discontinuation.
- Affiliations
Bambino Gesù Children’s Hospital, Rome Department of Medical and Surgical Neonatology
Citations
Auriti, C., Kieran, M. W., Deb, G., Devito, R., Pasquini, L., & Danhaive, O. (2008). Remission of infantile generalized myofibromatosis after interferon alpha therapy. Journal of Pediatric Hematology / Oncology, 30(2), 179-181. https://doi.org/10.1097/MPH.0b013e31815e62bb (Original work published 2008)