Endothelin-1 exacerbates diastolic stunning in conscious dogs.
(1993) American journal of physiology — Vol. 265, n° 5 Pt 2, p. H1688-95 (1993)
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- Abstract
- The purpose of this study was to examine the effects of endothelin-1 (ET-1) on "diastolic stunning" in the postischemic myocardium. In 14 conscious dogs receiving either placebo (n = 7) or ET-1 (2.5 ng.kg-1.min-1, n = 7), left ventricular (LV) hemodynamics and regional wall motion (systolic segmental shortening by sonomicrometry and the ischemic-nonischemic regional asynchrony during isovolumic relaxation) were assessed at baseline, during 10 min of left anterior descending coronary artery occlusion (CAO) and at 60 min after reflow (R-60). During CAO, the ischemic segment shortening was severely depressed and both regional asynchrony and LV relaxation time constant were significantly increased in the placebo and ET-1 groups. At R-60, this LV diastolic dysfunction recovered to baseline conditions in the placebo group but was still present in the ET-1 group. Because coronary and myocardial blood flow returned to the baseline level at R-60 in both groups, the deleterious effects of ET-1 on diastolic stunning are probably mediated by its direct action on the myocardium.
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Citations
Hayashida, W., Donckier, J., Van Mechelen, H., Stoleru, L., & Pouleur, H. (1993). Endothelin-1 exacerbates diastolic stunning in conscious dogs. American journal of physiology, 265(5 Pt 2), H1688-95. https://hdl.handle.net/2078.5/72391 (Original work published 1993)