Interaction between transforming Theileria parasites and their host bovine leukocytes.
(2021) Molecular microbiology — Vol. 115, n° 5, p. 860-869 (2021)
Files
2021_Tajeri_Mol_Microbiol.pdf
Open Access - Adobe PDF
- 844.12 KB
Details
- Authors
Tajeri, Shahin 
Haidar, Malak Sakura, Takaya Langsley, Gordon
- Abstract
- Theileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.
- Affiliations
Citations
Tajeri, S., Haidar, M., Sakura, T., & Langsley, G. (2021). Interaction between transforming Theileria parasites and their host bovine leukocytes. Molecular microbiology, 115(5), 860-869. https://doi.org/10.1111/mmi.14642 (Original work published 2021)