Correlating Exposure To Environmental Tobacco-smoke Exposure With Increased Incidence of Lung-cancer in Non Smokers - Is Cotinine a Valid Marker
(1994) The Cancer Journal (Print Edition) — Vol. 7, n° 3, p. 108-114 (1994)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- Environmental Tobacco Smoke (ETS) is a complex mixture of Exhaled Mainstream (EMS) and Sidestream Smoke (SS) composed of gases and Respirable Suspended Particles (RSP). It is both a highly diluted and an aged mixture the composition of which is difficult to assess. Based mainly on syllogisms it has been hypothesized that exposure to low levels of ETS increases the risk of lung cancer In nonsmokers. There is no question that nonsmokers living in the presence of smokers are exposed to tobacco smoke constituents. But, to conclude on the significance of such an exposure, in term of increased incidence of lung cancer in non smokers, can only rely on a quantitative biomonitoring of exposure to agents proven to play a causative role in lung carcinogenesis. Nether nicotine nor its metabolites are likely to be precise markers of exposure to such chemicals. Molecular epidemiology offers a promising, but still to be validated, tool to meet such a challenge by measuring proteins and/or DNA adducts in serum or urine samples.
- Affiliations
Citations
Roberfroid, MB. (1994). Correlating Exposure To Environmental Tobacco-smoke Exposure With Increased Incidence of Lung-cancer in Non Smokers - Is Cotinine a Valid Marker. The Cancer Journal (Print Edition), 7(3), 108-114. https://hdl.handle.net/2078.5/81903 (Original work published 1994)