Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial.

Durez, Patrick;Vandepapeliere, Pierre;Miranda, Pedro;Toncheva, Antoaneta;Boissier, Marie-Christophe;et.al.
(2014) PLoS One — Vol. 9, n° 12 (2014)

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Authors
  • Durez, PatrickUCLouvain
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  • Vandepapeliere, Pierre
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  • Miranda, Pedro
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  • Toncheva, Antoaneta
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  • Boissier, Marie-Christophe
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Abstract
Active immunization, or vaccination, with tumor necrosis factor (TNF)-Kinoid (TNF-K) is a novel approach to induce polyclonal anti-TNF antibodies in immune-mediated inflammatory diseases. This study was performed to transfer the proof of concept obtained in mice model of rheumatoid arthritis (RA) into human. We designed a pilot study to demonstrate the feasibility of therapeutic vaccination in RA.
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Durez, P., Vandepapeliere, P., Miranda, P., Toncheva, A., Berman, A., Kehler, T., Mociran, E., Fautrel, B., Mariette, X., Dhellin, O., Fanget, B., Ouary, S., Grouard-Vogel, G., & Boissier, M.-C. (2014). Therapeutic Vaccination with TNF-Kinoid in TNF Antagonist-Resistant Rheumatoid Arthritis: A Phase II Randomized, Controlled Clinical Trial. PLoS One, 9(12). https://doi.org/10.1371/journal.pone.0113465 (Original work published 2014)