Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE).
(2019) Journal of Rheumatology — Vol. 46, n° 9, p. 1215-1221 (2019)
Files
2019_Krabbe_J_Rheumatol.pdf
Open Access - Adobe PDF
- 10.95 MB
Details
- Authors
Krabbe, Simon 
Pedersen, Susanne J
- Abstract
- OBJECTIVE: To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. METHODS: After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. RESULTS: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κ ranged 0.35-0.77. CONCLUSION: Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
- Affiliations
Citations
Krabbe, S., Eshed, I., Gandjbakhch, F., Pedersen, S. J., Bird, P., Mathew, A. J., Lambert, R. G., Maksymowych, W. P., Glinatsi, D., Stoenoiu, M., Poggenborg, R., Jans, L., Jaremko, J. L., Herregods, N., Foltz, V., Conaghan, P. G., Althoff, C. E., Paschke, J., Peterfy, C., et al. (2019). Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE). Journal of Rheumatology, 46(9), 1215-1221. https://doi.org/10.3899/jrheum.181084 (Original work published 2019)