Development of Poly (dialkyl Methylidenemalonate) Nanoparticles As Drug Carriers

Mbela, TKM.;Poupaert, Jacques;Dumont, Pierre;Haemers, A.
(1993) International Journal of Pharmaceutics — Vol. 92, n° 1-3, p. 71-79 (1993)

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Authors
  • Mbela, TKM.
    Author
  • Poupaert, JacquesUCLouvain
    Author
  • Dumont, PierreUCLouvain
    Author
  • Haemers, A.
    Author
Abstract
Two novel dialkylmethylidenemalonate (DAMM) analogs: diallylmethylidenemalonate (AAMM, 1b) and cyclohexylethylmethylidenemalonate (CEMM, 1c) were synthesized and evaluated for their capacity to polymerise to stable nanoparticles and to adsorb primaquine diphosphate (PQ). PQ loading onto poly-AAMM (PAAMM, 1b) and poly-CEMM (PCEMM, 1c) was up to 90% in the pH range from 6.0 to 8.5. A significant improvement of the physicochemical characteristics and the PQ desorption capacity of the nanoparticles was achieved in this series of PDAMM analogs.
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Mbela, TKM., Poupaert, J., Dumont, P., & Haemers, A. (1993). Development of Poly (dialkyl Methylidenemalonate) Nanoparticles As Drug Carriers. International Journal of Pharmaceutics, 92(1-3), 71-79. https://doi.org/10.1016/0378-5173(93)90265-H (Original work published 1993)