Biological markers of eosinophil and neutrophil inflammation and bronchiolar epithelial damage in respiratory syncytial virus (RSV) bronchiolitis
(1997) Pediatric Pulmonology — Vol. 24, n° SUPPL. 16, p. 304- (1997)
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- Abstract
- RSV bronchiolitis is an important cause of morbidity in infancy. The symptoms include wheezing and the disease has been related to later development of childhood asthma. Although eosinophilic inflammation has been well described in the pathogenesis of asthma, little is known about eosinophil inflammation and the extent of epithelial damage in RSV bronchiolitis. Serum eosinophil cationic protein (ECP) released by activated eosinophils has been correlated to increased airway inflammation in asthmatics. Myeloperoxidase (MPO) released by neutrophils is used as a marker of neutrophilic inflammation. Clara cell protein (CCI6) is produced by non ciliated Clara Cells in the bronchiolar epithelium. CCI6 has been found decreased in the broncho alveolar lavage fluid of adult asthmatics. We therefore considered 14 patients admitted to the pédiatrie ward for RSV bronchiolitis and compared their serum levels of ECP, MPO and CCI6 with that of 14 controls with no respiratory disease. The presence of RSV in nasotracheal secretions of all bronchiolitis patients was confirmed by indirect immunofluorescence. The mean age of the patients was 10±6 months. Their SaO2 was 91.7±2% when admitted. Their mean total eosinophil count was 243.7±301.2/ml; their total IgE was 13.1215.24 IU/1. RSV Bronchiolitis Controls P value ECP(mcg/l) 26.1 ±19.5 11.9 ±7.4 p<0.001 CC16(mcg/l) 4.4 ±2.6 12.6 ±9.3 p <0.02 MPO (mcg/1) 113.1 ±76.4 175 ±97.4 NS We conclude that in this population of RSV bronchiolitis patients who needed hospital treatment, serum ECP was significantly increased when compared to controls suggesting the existence of eosinophilic inflammation to some extent. Serum MPO values did not suggest any significant neutrophil inflammation. Serum CCI6 values were lower in bronchiolitis patients than in controls possibly reflecting the bronchiolar epithelial damage associated with their condition. © 1997 Wiley-Liss, Inc.
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Godding, V., Galanti, L., Peterson, C., Bernardo, A., Sibille, Y., & Bodart, E. (1997). Biological markers of eosinophil and neutrophil inflammation and bronchiolar epithelial damage in respiratory syncytial virus (RSV) bronchiolitis. Pediatric Pulmonology, 24(SUPPL. 16), 304-. https://hdl.handle.net/2078.5/204570 (Original work published 1997)