Functional Electrical Stimulation-A New Therapeutic Approach to Enhance Exercise Intensity in Chronic Obstructive Pulmonary Disease Patients: A Randomized, Controlled Crossover Trial.

Medrinal, Clément;Prieur, Guillaume;Combret, Yann;Quesada, Aurora Robledo;Lamia, Bouchra;et.al.
(2018) Archives of Physical Medicine and Rehabilitation — Vol. 99, n° 8, p. 1454-1461 (2018)

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Authors
  • Medrinal, Clément
    Author
  • Prieur, Guillaume
    Author
  • Combret, YannUCLouvain
    Author
  • Quesada, Aurora Robledo
    Author
  • Lamia, Bouchra
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Abstract
OBJECTIVE: To evaluate the effect of quadriceps functional electrical stimulation (FES)-cycling on exertional oxygen uptake (V˙o2) compared with placebo FES-cycling in patients with chronic obstructive pulmonary disease (COPD). DESIGN: A randomized, single-blind, placebo-controlled crossover trial. SETTING: Pulmonary rehabilitation department. PARTICIPANTS: Consecutive patients (N=23) with COPD Global Initiative for Chronic Obstructive Lung Disease stage 2, 3, or 4 (mean forced expiratory volume during the first second, 1.4±0.4L [50.3% predicted]) who had recently begun a respiratory rehabilitation program. INTERVENTION: Two consecutive 30-minute sessions were carried out at a constant load with active and placebo FES-cycling. MAIN OUTCOME MEASURES: The primary outcome was mean V˙o2 during the 30-minute exercise session. The secondary outcomes were respiratory gas exchange and hemodynamic parameters averaged over the 30-minute endurance session. Lactate values, dyspnea, and perceived muscle fatigue were evaluated at the end of the sessions. RESULTS: FES-cycling increased the physiological response more than the placebo, with a greater V˙o2 achieved of 36.6mL/min (95% confidence interval [CI], 8.9-64.3mL/min) (P=.01). There was also a greater increase in lactate after FES-cycling (+1.5mmol/L [95% CI, .05-2.9mmol/L]; P=.01). FES-cycling did not change dyspnea or muscle fatigue compared with the placebo condition. CONCLUSIONS: FES-cycling effectively increased exercise intensity in patients with COPD. Further studies should evaluate longer-term FES-cycling rehabilitation programs. TRIAL REGISTRATION: ClinicalTrials.gov NCT02594722.
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Medrinal, C., Prieur, G., Combret, Y., Quesada, A. R., Debeaumont, D., Bonnevie, T., Gravier, F. E., Dupuis Lozeron, E., Quieffin, J., Contal, O., & Lamia, B. (2018). Functional Electrical Stimulation-A New Therapeutic Approach to Enhance Exercise Intensity in Chronic Obstructive Pulmonary Disease Patients: A Randomized, Controlled Crossover Trial. Archives of Physical Medicine and Rehabilitation, 99(8), 1454-1461. https://doi.org/10.1016/j.apmr.2018.02.002 (Original work published 2018)