Persistence of intraocular JC-virus associated with a MacTel phenotype

Hupin, Nathan;Hoogewoud, Florence;Sallo, Ferenc B.;Vermeirsch, Sandra;Guex-Crosier, Yan;et.al.
(2025) AIDS — Vol. 39, n° 9, p. 1307-1309 (2025)

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Authors
  • Hupin, NathanUCLouvain
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  • Hoogewoud, FlorenceDepartment of Ophthalmology, Jules-Gonin University Eye Hospital, FAA, Lausanne, Switzerland
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  • Sallo, Ferenc B.Department of Ophthalmology, Jules-Gonin University Eye Hospital, FAA, Lausanne, Switzerland
    Author
  • Vermeirsch, SandraDepartment of Ophthalmology, Jules-Gonin University Eye Hospital, FAA, Lausanne, Switzerland
    Author
  • Guex-Crosier, YanDepartment of Ophthalmology, Jules-Gonin University Eye Hospital, FAA, Lausanne, Switzerland
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Abstract
(en) The JC virus (JCV) is a polyomavirus known for establishing persistent, latent, and asymptomatic infections within the general population. Under conditions of compromised cellular immunity, notably in HIV infections, the virus can undergo reactivation and replication, leading to genomic rearrangements and acquisition of new tropisms, notably for the central nervous system where it can be responsible for progressive multifocal leukoencephalitis (PML). [...]
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Hupin, N., Hoogewoud, F., Sallo, F. B., Vermeirsch, S., Suttels, V., & Guex-Crosier, Y. (2025). Persistence of intraocular JC-virus associated with a MacTel phenotype. AIDS, 39(9), 1307-1309. https://doi.org/10.1097/QAD.0000000000004240 (Original work published 2025)