Editorial: Brain-Liver Axis and Glutamate Homeostasis.
(2022) Frontiers in neuroscience — Vol. 16, p. 879227 [1-2] (2022)
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- Glutamate has long been recognized as the main excitatory neurotransmitter. It requires the involvement of both neurons and glial cells to elicit its function as a neurotransmitter, in what has been known as a tripartite synapse (Martínez-Lozada and Ortega, 2015). Glutamate in the synaptic cleft is tightly regulated mostly by glial transporters, EAATs, avoiding overstimulation of glutamate receptors and preventing an excitotoxic insult (Danbolt, 2001). Glutamate taken up by astrocytes is converted to glutamine by glutamine synthetase and released and internalized by neurons to be converted back to glutamate through the glutamate/glutamine shuttle (McKenna et al., 2012; Martínez-Lozada and Ortega, 2015). [...]
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Jiménez-Torres, C., Najimi, M., & Ortega, A. (2022). Editorial: Brain-Liver Axis and Glutamate Homeostasis. Frontiers in neuroscience, 16, 879227 [1-2]. https://doi.org/10.3389/fnins.2022.879227 (Original work published 2022)