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Abstract
hMT+/V5, a region long thought to specialize for visual motion, also responds to auditory motion in sighted and even more so in congenitally blind people. The mechanisms behind auditory motion information transfer to the "visual" motion area in sighted and congenitally blind individuals remains unknown. Our study characterizes layer-dependent activity to visual and auditory motion in hMT+/V5 and Planum Temporale (hPT) of blind and sighted individuals using ultra-high-field fMRI (7T), in order to define the feedback or feedforward nature of information exchange in this audio-visual motion selective network. In sighted people, we hypothesize that hMT+/V5 and hPT receive feedforward visual and auditory input in middle layers, respectively; and send feedback signals to superficial and/or deeper layers of the counterpart motion area. Additionally, we aim to explore how these feedforward and feedback connections reorganized due to visual deprivation. To do so, we relied on ultra high-field 7T fMRI with VASO submillimeter resolution acquitsition involving both sighted (n. 12) and blind individuals (n. 10) processing horizontal and vertical motion stimuli presented in vision (in the sighted group) and audition (in both groups). Preliminary findings from a subset of participants (n. 3 per group) suggest prevalent visual feedforward activity within hMT+/V5 for sighted participants and a similar feedforward activity for auditory input among blind individuals. Further analysis will validate these findings and explore directional motion encoding across layers, modalities and motion areas in both groups.
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Barilari, M., Matuszewski, J., Gau, R., Giraudet, E., Van Baelen, M., Sherif, S., Huber, R., & Collignon, O. (2024). Characterizing layer-dependent activity to visual and auditory motion in hMT+/V5 of blind and sighted individuals using ultra-high-field fMRI (7T). BAPS 2024 - VUB, Bruxelles. https://hdl.handle.net/2078.5/239783