1-aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

Beadle, CD;Boot, J;Camp, NP;Dezutter, N;Walter, MW;et.al.
(2005) Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology — Vol. 15, n° 20, p. 4432-4437 (2005)

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Authors
  • Beadle, CD
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  • Boot, J
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  • Camp, NP
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  • Dezutter, N
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  • Walter, MW
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Abstract
A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion. (c) 2005 Elsevier Ltd. All rights reserved.
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Beadle, C., Boot, J., Camp, N., Dezutter, N., Findlay, J., Hayhurst, L., Masters, J., Penariol, R., & Walter, M. (2005). 1-aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors. Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, 15(20), 4432-4437. https://doi.org/10.1016/j.bmcl.2005.07.038 (Original work published 2005)