A concise total synthesis of the lichen macrolide (+)-aspicilin.
(2006) Organic Letters — Vol. 8, n° 22, p. 5137-5140 (2006)
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- Abstract
- The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield. [structure: see text]
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Dubost, C., Marko, I., & Ryckmans, T. (2006). A concise total synthesis of the lichen macrolide (+)-aspicilin. Organic Letters, 8(22), 5137-5140. https://doi.org/10.1021/ol0620287 (Original work published 2006)