Evaluation of a DNA microarray (Check-MDR CT102) for rapid detection of TEM, SHV, and CTX-M extended-spectrum β-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases.

Naas, Thierry;Cuzon, Gaelle;Bogaerts, Pierre;Glupczynski, Gerald;Nordmann, Patrice
(2011) Journal of Clinical Microbiology — Vol. 49, n° 4, p. 1608-1613 (2011)

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Authors
  • Naas, Thierry
    Author
  • Cuzon, Gaelle
    Author
  • Bogaerts, Pierre
    Author
  • Glupczynski, GeraldUCLouvain
    Author
  • Nordmann, Patrice
    Author
Abstract
The Check-MDR CT102 microarray, aimed at identifying bacteria producing extended-spectrum β-lactamase (ESBL) (SHV, TEM, and CTX-M) and carbapenemase (KPC, OXA-48, VIM, IMP, and NDM-1), was evaluated on a total of 144 Gram-negative strains expressing various β-lactamases. The sensitivity and specificity were 100% for most tested genes, suggesting that this assay allows accurate identification of common ESBL and carbapenemase producers from bacterial cultures.
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Naas, T., Cuzon, G., Bogaerts, P., Glupczynski, G., & Nordmann, P. (2011). Evaluation of a DNA microarray (Check-MDR CT102) for rapid detection of TEM, SHV, and CTX-M extended-spectrum β-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases. Journal of Clinical Microbiology, 49(4), 1608-1613. https://doi.org/10.1128/JCM.02607-10 (Original work published 2011)