We describe a case of spontaneous complex regional pain syndrome developing first in the left arm and 2 years later in the right foot of a 14-year-old girl. Physical examination showed abnormalities in tactile and thermal sensitivity. Laser-evoked potentials (LEPs) after stimulation of the affected right foot were absent in the acute phase and then progressively recovered over a period of 5 months, in correlation with clinical changes. To our knowledge, no systematic analysis of LEPs in complex regional pain syndrome has been published. We suggest that the observed electrophysiologic alterations could result from a temporary dysfunction of attentional systems, which are assumed to contribute greatly to the LEPs vertex complex. Further studies are needed to test this hypothesis.
Moreau, V., Berquin, A., & Plaghki, L. (2007). Laser-evoked potentials correlate with clinical evolution in a case of spontaneous and recurrent complex regional pain syndrome type I. Clinical Journal of Pain, 23(4), 375-379. https://doi.org/10.1097/AJP.0b013e3180332d7f (Original work published 2007)