Recombinant Interleukin-2 in Metastatic Renal-cell Carcinoma - a European Multicenter Phase-ii Study
(1991) European Journal of Cancer — Vol. 27, n° 12, p. 1583-1589 (1991)
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- Abstract
- This multinational, multicentre study represents the introduction of recombinant interleukin-2 (rIL-2) in Europe. From December 1987 to June 1989, 57 eligible patients with metastatic renal cell cancer were treated with rIL-2 administered as continuous intravenous infusion. 8 out of 51 evaluable patients responded (16%), 2 complete remission (CR) and 6 partial remission (PR). 10 patients had no change (20%). The response duration for CR was 209 and 394+ days. The median response duration for PR was 371 (range 140-506+) days. Dose-limiting grade 3-4 toxicities were hypotension in 52% of the patients, arrhythmia (4%), dyspnoea (8%), creatinine rise (4%), peripheral neurotoxicity (10%) and central neurotoxicity (10%). Toxicities most often recovered solely on interrupted therapy. 2 patients died due to catheter-related septicaemia and one patient died of rIL-2 induced renal failure. The study confirmed the antitumour efficacy of rIL-2 in renal cell cancer. Toxicities were numerous, but manageable by close observation in a normal oncology ward without routine use of an intensive care unit.
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Vondermaase, H., Geertsen, P., Thatcher, N., Jasmin, C., Mercatello, A., Fossa, SD., Symann, M., Stoter, G., Nagel, G., Israel, L., Oskam, R., Palmer, P., & Franks, CR. (1991). Recombinant Interleukin-2 in Metastatic Renal-cell Carcinoma - a European Multicenter Phase-ii Study. European Journal of Cancer, 27(12), 1583-1589. https://hdl.handle.net/2078.5/137277 (Original work published 1991)