Longitudinal distributionn of isomyosins in normal and regenerating extensor digitorum longus of the rat
(1991) Basic and Applied Myology : European journal of translational myology — Vol. 1, n° 1, p. 55-61 (1991)
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- Authors
Maréchal, Georges 
- Abstract
- Extensor digitorum longus (EDL) muscle of rat were cut perpendicularly to their long axis in three parts. The proximal, middle and distal parts of the muscles were analyzed for their proportions in myosin heavy chains, isomyosins and type I fibres. Proximal sections contain relatively more myosin heavy chains MHC2A, whilst the reverse is true for distal sections, which contain relatively more myosin heavy chains MHC2B.The proportions of isomyosin FM3 are highest proximally; those of FM2 are highest distally; the proportions of FM1 are constant along the length of the muscle. One may thus infer from our observations that the distal end is proportionally richer in LC3f than in LC1f when compared to the proximal end. Intermediate isomyosin, IM, is localized proximally in the few EDL muscles where it is present. Type I fibres are preferentially localized in a medio-anterior area. This area is larger at the proximal end than at the distal end, and consequently, the proportion of type I fibres is highest at the proximal end. These observations indicate that EDL muscle contract faster at its distal end than at its proximal end. EDL muscle regenerating from a mince up to 120 days have lost the spatial distribution of fibres observed in the control muscle.
Citations
Moens, P., & Maréchal, G. (1991). Longitudinal distributionn of isomyosins in normal and regenerating extensor digitorum longus of the rat. Basic and Applied Myology : European journal of translational myology, 1(1), 55-61. https://hdl.handle.net/2078.5/214350 (Original work published 1991)