Enzymic N-demethylation reaction catalysed by red blood cell cytosol.
(1992) Biochemical Pharmacology — Vol. 43, n° 2, p. 207-211 (1992)
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- Abstract
- Red blood cell cytosol promotes enzymic N-demethylation reactions which display typical Michaelis-Menten kinetics with respect to N-methylaniline as substrate. The demethylase activity is linked with hemoglobin (Hb) and is enhanced in the presence of NADH and the NADH-methemoglobin reductase system. It has been adduced that Hb in its oxygenated form is involved in the reaction.
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Stecca, C., Cumps, J., & Duverger-Van Bogaert, M. (1992). Enzymic N-demethylation reaction catalysed by red blood cell cytosol. Biochemical Pharmacology, 43(2), 207-211. https://doi.org/10.1016/0006-2952(92)90279-R (Original work published 1992)