Acute polyneuropathy after malathion poisoning

Monje Argiles, A.;Lison, Dominique;Lauwerys, Robert;Mahieu, P.;Van den Bergh, Peter;et.al.
(1990) Acta Neurologica Belgica — Vol. 90, n° 4, p. 190-199 (1990)

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Authors
  • Monje Argiles, A.
    Author
  • Lison, Dominiqueorcid-logoUCLouvain
    Author
  • Lauwerys, RobertUCLouvain
    Author
  • Mahieu, P.
    Author
  • Brucher, Jean-MarieUCLouvain
    Author
  • Van den Bergh, PeterUCLouvain
    Author
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Abstract
We report a patient in whom intoxication with a commercial preparation of malathion led to a severe acute cholinergic crisis, protracted cardiac arrhythmias, an acute respiratory distress syndrome, and an acute sensorimotor axonal polyneuropathy. The occurrence of the polyneuropathy was associated with a novel malathion transformation product, S-(1-ethoxycarbonyl, 2-isopropoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate (isopropylmalathion), an impurity present in the pesticide residue. The role of isopropylmalathion in the pathophysiology of the polyneuropathy remains to be determined.
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Monje Argiles, A., Lison, D., Lauwerys, R., Mahieu, P., Brucher, J.-M., & Van den Bergh, P. (1990). Acute polyneuropathy after malathion poisoning. Acta Neurologica Belgica, 90(4), 190-199. https://hdl.handle.net/2078.5/134222 (Original work published 1990)