Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction.
(2006) Organic Letters — Vol. 8, n° 26, p. 5943-5946 (2006)
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- Abstract
- [Structure: see text] An efficient method for the enantioselective tandem reductive aldol reaction of methyl acrylate with aldehydes is reported. By using a copper(I) precursor and a proper diphosphane ligand, high reactivities can be reached, with TOF up to 40,000 h-1. Taniaphos-based ligands lead to enantioselectivities of up to 97% in the case of the major syn diastereoisomer.
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Chuzel, O., Deschamp, J. O., Chausteur, C., & Riant, O. (2006). Copper(I)-catalyzed enantio- and diastereoselective tandem reductive aldol reaction. Organic Letters, 8(26), 5943-5946. https://doi.org/10.1021/ol062398v (Original work published 2006)