Copper-catalyzed one-pot borylative aldolisation β-fluoride elimination for the formal addition of acrylates to carbonyl moieties

Rasson, Corentin;Stouse, Adrien;Boreux, Arnaud;Cirriez, Virginie;Riant, Olivier
(2018) Chemistry: A European Journal — Vol. 24, n° 37, p. 9234-9237 (2018)

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  • Rasson, Corentin
    Author
  • Stouse, Adrien
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  • Boreux, ArnaudUCLouvain
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  • Cirriez, Virginie
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  • Riant, Olivierorcid-logoUCLouvain
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Abstract
Herein, we report the copper-catalyzed domino borylation/aldolisation of methyl 2-fluoroacrylate with carbonyl compounds followed by an elimination to give Morita–Baylis–Hillman (MBH) analogues. The optimal conditions described were shown to be compatible with a wide range of aldehydes and ketones. Unprecedented MBH adducts derived from ketones were efficiently synthesized.
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Rasson, C., Stouse, A., Boreux, A., Cirriez, V., & Riant, O. (2018). Copper-catalyzed one-pot borylative aldolisation β-fluoride elimination for the formal addition of acrylates to carbonyl moieties. Chemistry: A European Journal, 24(37), 9234-9237. https://doi.org/10.1002/chem.201802023 (Original work published 2018)