A MAGE-1 peptide recognized on HLA-DR15 by CD4(+) T cells.

Chaux, P;Lethé, B;Van Snick, Jacques;Corthals, J;van der Bruggen, Pierre;et.al.
(2001) European journal of immunology — Vol. 31, n° 6, p. 1910-1916 (2001)

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Authors
  • Chaux, P
    Author
  • Lethé, B
    Author
  • Van Snick, JacquesUCLouvain
    Author
  • Corthals, J
    Author
  • Cambiaso, CesarUCLouvain
    Author
  • Boon, ThierryUCLouvain
    Author
  • van der Bruggen, PierreUCLouvain
    Author
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Abstract
Antigens encoded by MAGE genes and recognized by T cells are of interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. Several MAGE-1 peptide that are recognized by CD8(+) cytolytic T lymphocytes have been used in therapeutic vaccination trials. To obtain anti-tumor immune response, vaccines combining peptides recognized by CD8(+) and peptides recognized by CD4(+) T cells might be optimal. We focused therefore on the identification of MAGE peptides recognized by CD4(+) T cells. We report here the identification of MAGE-1 epitope EYVIKVSARVRF, which is presented to CD4(+) T lymphocytes by HLA-DR15. This HLA allele is present in 29 % of Asians and 17 % of Caucasians.
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Chaux, P., Lethé, B., Van Snick, J., Corthals, J., Schultz, E. S., Cambiaso, C., Boon, T., & van der Bruggen, P. (2001). A MAGE-1 peptide recognized on HLA-DR15 by CD4(+) T cells. European journal of immunology, 31(6), 1910-1916. https://doi.org/10.1002/1521-4141(200106)31:6<1910::AID-IMMU1910>3.0.CO;2-K (Original work published 2001)