Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.

Marquez, Béatrice;Pourcelle, Vincent;Vallet, Coralie M;Mingeot-Leclercq, Marie-Paule;Van Bambeke, Françoise;et.al.
(2014) Pharmaceutical Research — Vol. 31, n° 5, p. 1290-1301 (2014)

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Authors
  • Marquez, Béatrice
    Author
  • Pourcelle, VincentUCLouvain
    Author
  • Vallet, Coralie M
    Author
  • Mingeot-Leclercq, Marie-PauleUCLouvain
    Author
  • Tulkens, Paul M.UCLouvain
    Author
  • Marchand-Brynaert, JacquelineUCLouvain
    Author
  • Van Bambeke, Françoiseorcid-logo
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Abstract
To evaluate pharmacological properties (antibacterial activity; accumulation in phagocytic cells; activity against intracellular bacteria; susceptibility to fluoroquinolone efflux transporters) of ciprofloxacin derivatives modified at C-7 of the piperazine ring.
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Marquez, B., Pourcelle, V., Vallet, C. M., Mingeot-Leclercq, M.-P., Tulkens, P. M., Marchand-Brynaert, J., & Van Bambeke, F. (2014). Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity. Pharmaceutical Research, 31(5), 1290-1301. https://doi.org/10.1007/s11095-013-1250-x (Original work published 2014)