IL-22 functions as both a proinflammatory cytokine and an anti-inflammatory cytokine in various inflammations, depending on the cellular and cytokine milieu. However, the roles of IL-22 in the regulation of allergic airway inflammation are still largely unknown.
Takahashi, K., Hirose, K., Kawashima, S., Niwa, Y., Wakashin, H., Iwata, A., Tokoyoda, K., Renauld, J.-C., Iwamoto, I., Nakayama, T., Nakajima, H., & et al. (2011). IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. Journal of Allergy and Clinical Immunology, 128(5), 1067-1076. https://doi.org/10.1016/j.jaci.2011.06.018 (Original work published 2011)