Effect of tobacco and nicotine replacement therapy on biomarkers associated with endothelial dysfunction
(2023)
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- Abstract
- Tobacco use is a major cause of cardiovascular diseases (CVDs), which begin with endothelial dysfunction. In this thesis, we objectified, by the quantification of specific biomarkers, an elevation of inflammation, oxidative stress, and endothelial activation in smokers, associated with an altered lipid profile. All these processes are involved in endothelial dysfunction and therefore, promote CVDs development. We found that these effects could be reversible on quitting. These improvements were already visible at short term. The role of nicotine, especially of nicotine replacement therapy (NRT), in CVDs progression remains controversial in the literature. Therefore, we assessed the influence of NRT on biomarkers and we demonstrated that they did not affect the biological improvements observed with smoking cessation.
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Citations
Colsoul, M.-L. (2023). Effect of tobacco and nicotine replacement therapy on biomarkers associated with endothelial dysfunction. https://hdl.handle.net/2078.5/106245