Investigating bioactive lipid- and microRNA-loaded extracellular vesicles to target neuroinflammation

Auquière, Marie
(2026)

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des Rieux, Anne  
 ;
Muccioli, Giulio  
Abstract
(en) Neuroinflammation is a central feature of several neurodegenerative diseases and contributes significantly to disease progression. Effective therapeutic strategies remain limited. In recent years, extracellular vesicles (EV) have emerged as innovative and promising drug delivery systems. In this context, loading therapeutic molecules within EV may enhance drug delivery and therapeutic efficacy. This thesis aimed to develop bioactive lipid- and microRNA-loaded EV designed to target and alleviate neuroinflammation. To this end, multiple aspects of EV loading were investigated, the choice of EV source was critically evaluated, and the therapeutic potential of 15d-PGJ2- and miR-181c-loaded EV was assessed. This work underscored both the potential and the limitations of EV-mediated delivery of therapeutic molecules.
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Auquière, M. (2026). Investigating bioactive lipid- and microRNA-loaded extracellular vesicles to target neuroinflammation. https://hdl.handle.net/2078.5/279770