The VASCERN-VASCA diagnostic and management pathways for kaposiform hemangioendothelioma
(2026) European Journal of Pediatrics — Vol. 185, n° 14 (2025)
Files
GASPARELLA-2025-EurJPed.pdf
Open Access - Adobe PDF
- 1.93 MB
Details
- Authors
- Abstract
- The European Reference Network (ERN) on Rare Multisystemic Vascular Diseases (VASCERN) is dedicated to gathering the best expertise in Europe in order to improve and provide high-level healthcare to all patients with rare vascular diseases and provide accessible cross-border healthcare to patients with rare vascular diseases. Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumour with local aggressiveness, often associated with a life-threatening coagulopathy known as the Kasabach-Merritt phenomenon (KMP). The Vascular Anomalies Working Group (VASCA-WG) developed diagnostic and therapeutic pathways for the management of KHE using the nominal group technique (NGT), a well-established, struc- tured, multi-stage, facilitated group meeting technique used to generate consensus statements. The pathways were developed following two face-to-face meetings and several web meetings to facilitate discussion. Conclusion: VASCA has produced this expert opinion, which reflects the strategies developed by experts and patient rep- resentatives on how to approach patients with Kaposiform Hemangiothelioma in a practical manner; here, we present an algorithmic flow chart of this work.
- Affiliations
Medical University of Graz Department of Paediatric and Adolescent Surgery Oslo University Hospital Department of Radiology and Nuclear Medicine VASCAPA Vascular Anomaly Patient Association Hospital Sant Joan de Deu Pediatric Dermatology AP-HP, Université de Paris, Hôpital Lariboisière Centre Constitutif Des Malformations Artério Veineuses Superficielles de L’Enfant Et de L’Adulte, Neuroradiologie Bundesverband Angeborene Gefäßfehlbildungen E.V. Federal Association of Congenital Vascular Malformation Centro Hospitalar Universitário São João Pediatric Oncology Centro Hospitalar Universitário São João Interventional Radiology Victor Babes University of Medicine and Pharmacy Department of Microscopic Morphology/Histology Bambino Gesù Children’s Hospital Dermatology Unit and Genodermatosis Unit, Translational Pediatrics and Clinical Genetics Research Area Children’s Health IrelandTrinity College Dublin Paediatric Dermatology Karolinska University Hospital Department of Clinical Genetics Karolinska University Hospital Department of Reconstructive Plastic and Craniofacial Surgery University of Freiburg Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine Copenhagen University Hospital Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet Copenhagen University Hospital Department of Clinical Genetics University Hospital Brno Department of Pediatric Oncology University of Helsinki and Helsinki University Hospital Department of Pediatric Surgery University of Helsinki and Helsinki University Hospital Department of Internal Medicine Vilnius University Faculty of Medicine, Vilnius University Hospital Santaros Klinikos Medical University of Lodz Department of Pediatric Surgery and Oncology Radboud University Medical Center Department of Dermatology Radboud University Medical Center Department of Radiology
Citations
Gasparella, P., Haxhija, E. Q., Andersen, R., Barea, M., Baselga, E., Serrano, M. B., Berger, S., Bisdorff, A. A., Boccara, O., Borgards, P., Bom-Sucesso, M., Boon, L., Cimpean, A. M., Diociaiuti, A., Dvorakova, V., Hachem, M. E., Frisk, S., Ghaffarpour, N., Holm, A., et al. (2026). The VASCERN-VASCA diagnostic and management pathways for kaposiform hemangioendothelioma. European Journal of Pediatrics, 185(14). https://doi.org/10.1007/s00431-025-06631-6 (Original work published 2025)