Here, we present an overview of different types of nanostructured heterogeneous catalysts and we explain why this peculiar mode of preparation has allowed reaching enhanced performance in various applications including olefin metathesis,[3] ethyl lactate synthesis,[4] olefin epoxidation,[5] (trans)-esterification,[6] CO2 methanation.[7] We also describe the one-step synthesis of surface functionalized hybrid catalysts demonstrate the concept of bi-functional hybrid catalyst, active for example in the upgrading of glycerol to solketal.[8] Finally, we will turn to hybrid chemo-enzymatic heteroegenous catalysts (HCEHC), demonstrating the successful combination of a nano-zeolite and an enzyme to run chemo-enzymatic cascade reactions.[9]