Die Pankreasgängigkeit von Antibiotica.

Koch, K;Drewelow, B;Liebe, S;Reding, Raymond;Riethling, A K
(1991) Der Chirurg : Zeitschrift für alle Gebiete der operativen Medizin — Vol. 62, n° 4, p. 317-322 (1991)

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Authors
  • Koch, K
    Author
  • Drewelow, B
    Author
  • Liebe, S
    Author
  • Reding, RaymondUCLouvain
    Author
  • Riethling, A K
    Author
Abstract
Antibiotic therapy is indicated in acute pancreatitis because the most common complication and the mean reason for mortality is a bacterial infection. Concentrations of nine antibiotics from various classes were studied in the pancreatic tissue and pancreatic juice of patients and dogs. The volume of distribution is the most valuable parameter for predicting the potential pancreatic penetration of a substance. As a result of our pharmacokinetic studies mezlocillin and cefotiam, especially ciprofloxacin, have the most antiinfectious potential in treatment of acute pancreatitis. Metronidazole is suitable for combination in cases of pancreatic infections covering anaerobic bacteria.
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Koch, K., Drewelow, B., Liebe, S., Reding, R., & Riethling, A. K. (1991). Die Pankreasgängigkeit von Antibiotica. Der Chirurg : Zeitschrift für alle Gebiete der operativen Medizin, 62(4), 317-322. https://hdl.handle.net/2078.5/88270 (Original work published 1991)