Multishell diffusion-weighted MRI characterization of chronic active lesions in Multiple Sclerosis

Stölting, Anna;Vanden Bulcke, Colin;Jelinkova, Dominika;Gaëtan Duchêne;Maggi, Pietro;et.al.
(2023) European Acadamy of Neurology — Location: Budapest, Hungary (1.July.2023)

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Abstract
Chronic active Multiple Sclerosis (MS) lesions, seen on susceptibility-weighted MRI as Paramagnetic Rim Lesions (PRL), are associated with increased clinical disability and axonal damage. Diffusion MRI (dMRI) can characterize in vivo PRL’s tissue damage, however the tissue microstructure specificity of dMRI models is limited. Here, we characterized PRL’s microstructure using 4 different models, including one novel dMRI model: Microstructure Fingerprinting (MF).
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Stölting, A., Vanden Bulcke, C., Jelinkova, D., Gaëtan Duchêne, Dricot, L., Macq, B., & Maggi, P. (2023). Multishell diffusion-weighted MRI characterization of chronic active lesions in Multiple Sclerosis. EUROPEAN JOURNAL OF NEUROLOGY - Abstracts of the 9th Congress of the European Academy of Neurology, 30, 706. https://hdl.handle.net/2078.5/102887 (Original work published 2023)