To the Editor, We read with great interest the comments by Heersche et al. on our recent article examining on almost 20,000patients the concordance between pre-emptive DPDphenotyping (uracil (U)±dihydrouracil (UH2)) and targetedDPYDgenotyping including *2A, *13, p.D949V and *7variants. As widely discussed in the main article, onelimitation of our study is that haplotype B3 was not tested. Ofnote, our study included the very scarce *7 variant, designedas a non-functional allele by the CPIC. [...]
Thomas, F., Launay, M., Raymond, L., Guitton, J., Loriot, M.-A., Chatelut, E., Haufroid, V., & Etienne-Grimaldi, M.-C. (2024). Reply to: “Is uracil enough for effective pre-emptive DPD testing?”. Clinical Chemistry and Laboratory Medicine : Associated with FESCC and IFCC, 62(12), e257-e259. https://doi.org/10.1515/cclm-2024-0889 (Original work published 2024)