Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin's lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy.

Gauthier, Jordan;Poire, Xavier;Gac, Anne-Claire;Leclerc, Mathieu;Yakoub-Agha, Ibrahim;et.al.
(2018) Bone Marrow Transplantation — Vol. 53, n° 4, p. 400-409 (2018)

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  • Gauthier, Jordan
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  • Poire, XavierUCLouvain
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  • Gac, Anne-Claire
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  • Leclerc, Mathieu
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  • Yakoub-Agha, Ibrahim
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Abstract
The question of the best donor type between haploidentical (HAPLO) and matched-related donors (MRD) for patients with advanced HL receiving an allogeneic hematopoietic cell transplantation (allo-HCT) is still debated. Given the lack of data comparing these two types of donor in the setting of non-myeloablative (NMA) or reduced-intensity (RIC) allo-HCT, we performed a multicentre retrospective study using graft-vs.-host disease-free relapse-free survival (GRFS) as our primary endpoint. We analysed the data of 151 consecutive HL patients who underwent NMA or RIC allo-HCT from a HAPLO (N  =  61) or MRD (N  =  90) between January 2011 and January 2016. GRFS was defined as the probability of being alive without evidence of relapse, grade 3-4 acute GVHD or chronic GVHD. In multivariable analysis, MRD donors were independently associated with lower GRFS compared to HAPLO donors (HR  =  2.95, P   < 0.001). Disease status at transplant other than CR was also associated with lower GRFS in multivariable analysis (HR  =  1.74, P  =  0.01). In addition, the administration of ATG was independently linked to higher GRFS (HR  =  0.52, P  =  0.009). In summary, we observed significantly higher GRFS in HL patients receiving an allo-HCT using the HAPLO PT-Cy platform compared to MRD.
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Gauthier, J., Poire, X., Gac, A.-C., Leclerc, M., Guillaume, T., Chalandon, Y., Nguyen, S., Forcade, E., Régny, C., Bay, J.-O., Bazarbachi, A., Rohrlich, P.-S., Huynh, A., Farhi, J., Marchand, T., Malfuson, J.-V., Pilorge, S., Labussière-Wallet, H., Renard, C., et al. (2018). Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin’s lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy. Bone Marrow Transplantation, 53(4), 400-409. https://doi.org/10.1038/s41409-017-0018-z (Original work published 2018)