Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus.

Bommer, Guido;MacDougald, Ormond A
(2011) Cell Metabolism — Vol. 13, n° 3, p. 241-247 (2011)

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  • Bommer, Guidoorcid-logoUCLouvain
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  • MacDougald, Ormond AUniversity of Michigan
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Abstract
The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis.
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Bommer, G., & MacDougald, O. A. (2011). Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell Metabolism, 13(3), 241-247. https://doi.org/10.1016/j.cmet.2011.02.004 (Original work published 2011)