Using the nature of the achiral solvent to orient chiral resolution

de Meester, Joséphine;Shemchuk, Oleksii;Collard, Laurent;Wouters, Johan;Leyssens, Tom;et.al.
(2024) CrystEngComm — Vol. 26, n° 15, p. 2056-2059 (2024)

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Authors
  • de Meester, JoséphineUCLouvain
    Author
  • Shemchuk, OleksiiUCLouvain
    Author
  • Collard, LaurentUCLouvain
    Author
  • Wouters, JohanUNamur
    Author
  • Baillieux, SimonUCLouvain
    Author
  • Robeyns, Koenorcid-logoUCLouvain
    Author
  • Leyssens, Tomorcid-logoUCLouvain
    Author
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Abstract
We demonstrate the unprecedented phenomenon of solvent-oriented resolution of 1,1′-bi-2-naphtol (Binol). Using a resolution agent of a fixed handedness (R,R)-N,N′-dimethyl-1,2-diphenylethane-1,2-diamine (DADPE), we are able to resolve either the (S)- or (R)-enantiomer of Binol by a mere change of the achiral solvent.
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de Meester, J., Shemchuk, O., Collard, L., Wouters, J., Baillieux, S., Robeyns, K., & Leyssens, T. (2024). Using the nature of the achiral solvent to orient chiral resolution. CrystEngComm, 26(15), 2056-2059. https://doi.org/10.1039/d4ce00124a (Original work published 2024)