Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity

Vanbel, PF.;Gilliard, JA.;Tilquin, Bernard
(1993) 19TH INTERNATIONAL SYMP ON CHROMATOGRAPHY — Location: AIX EN PROVENCE(France) (13.September.1992)

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Authors
  • Vanbel, PF.
    Author
  • Gilliard, JA.
    Author
  • Tilquin, BernardUCLouvain
    Author
Abstract
Optimization procedures require adequate response criteria to assess the quality of each chromatogram obtained during the process. The objective of this paper is to evaluate the possibility of using different resolution functions, in the chromatographic separation of a drug and its impurities (particularly the impurity just eluted after the drug). This study shows the limits of some resolution expressions. The interest of the simple DELTAt criterion, the difference between retention times, is presented in this paper.
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Vanbel, PF., Gilliard, JA., & Tilquin, B. (1993). Chemometric Optimization in Drug Analysis By Hplc - a Critical-evaluation of the Quality Criteria Used in the Analysis of Drug Purity. Chromatographia, 36, 120-124. https://doi.org/10.1007/BF02263847 (Original work published 1993)