Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane.
(1989) Surgery — Vol. 105, n° 5, p. 690-692 (1989)
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- Abstract
- A 62-year-old man arrived at our hospital with recurrence of Cushing's syndrome 14 years after successful surgery for adrenocortical carcinoma. Investigations demonstrated recurrence of a large tumor above the right adrenal area; it was found to be inoperable. The patient was treated initially with a new glucocorticoid antagonist, RU 486, and later with the adrenolytic agent mitotane (o,p'DDD). The latter achieved hypoadrenocorticism and a substantial reduction of tumor size. During the initial period, worsening hyperadrenocorticism resulted in a rise of atrial natriuretic factor and an inhibition of renin activity, consistent with an increase of cortisol and plasma volume. Changes in opposite direction were observed after treatment with mitotane.
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Citations
Donckier, J., Michel, L., Berbinschi, A., De Coster, P., De Plaen, J., Ketelslegers, J.-M., & Buysschaert, M. (1989). Late recurrence of operated adrenocortical carcinoma: atrial natriuretic factor before and after treatment with mitotane. Surgery, 105(5), 690-692. https://hdl.handle.net/2078.5/88246 (Original work published 1989)