Gallbladder mass with a carbohydrate antigen 19-9 level in the thousands: malignant or benign pathology? Report of a case.
(2007) Surgery Today : the Japanese journal of surgery — Vol. 37, n° 4, p. 342-344 (2007)
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- Authors
- Abstract
- Tumor markers such as carbohydrate antigen 19-9 (CA 19-9) are commonly measured in the serum of patients with suspected pancreaticobiliary malignancies. Moderate elevations of CA 19-9 may be seen in benign disease, but levels in the thousands are indicative of malignancy. We report the case of a 64-year-old man with an elevated CA 19-9 of 5791 U/ml and radiological findings suggestive of metastatic gallbladder carcinoma. The patient underwent cholecystectomy and excision of a common bile duct stricture, with hepaticojejunostomy and liver biopsy. The final surgical pathology was consistent with xanthogranulomatous cholecystitis (XGC) and the elevated CA 19-9 returned to normal postoperatively. Thus, an elevated CA 19-9 level, even in the thousands, should not preclude patients from an operation if a mass is deemed resectable. Thorough investigation and treatment may result in a curative operation even if unresectable malignant disease is initially suspected.
- Affiliations
Keck School of Medicine, University of Southern California, Univeristy Hospital, Los Angeles (USA) Division of Hepatobiliary/Pancreatic Surgery and Abdominal Organ Transplantation
Citations
Clarke, T., Matsuoka, L., Jabbour, N., Mateo, R., Genyk, Y., Selby, R., & Gagandeep, S. (2007). Gallbladder mass with a carbohydrate antigen 19-9 level in the thousands: malignant or benign pathology? Report of a case. Surgery Today : the Japanese journal of surgery, 37(4), 342-344. https://doi.org/10.1007/s00595-006-3377-4 (Original work published 2007)