Design, synthesis and evaluation of D,D-peptidase and beta-lactamase inhibitors: azapeptides, oxapeptides and related heterocycles.
(1995) Il Farmaco — Vol. 50, n° 6, p. 455-469 (1995)
Files
No attached file found for this publication.
Details
- Authors
- Abstract
- Reactive molecules susceptible to form stable acyl enzyme intermediates with D,D-peptidases and beta-lactamases were designed as potential irreversible inhibitors of Penicillin Sensitive Enzymes (PSEs). The structures examined were a series of azapeptides and oxapeptides, both analogs of the D-Ala-D-Ala substrate, and some heterocycles, such as imidazolidinones and oxazolidinones, both analogs of the beta-lactam antibiotics. The various strategies investigated for their synthesis are described and discussed. Some biological results are reported.
- Affiliations
Citations
Marchand-Brynaert, J., Mougenot, P., Combret, Y., Belotti, D., Guillot, N., & Ghosez, L. (1995). Design, synthesis and evaluation of D,D-peptidase and beta-lactamase inhibitors: azapeptides, oxapeptides and related heterocycles. Il Farmaco, 50(6), 455-469. https://hdl.handle.net/2078.5/134805 (Original work published 1995)