FcαRI-mediated inhibition of IL-12 production and priming by IFN-γ of human monocytes and dendritic cells
(2013) Journal of Immunology — Vol. 190, n° 5, p. 2362-2371 (2013)
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- We showed that IgA induces IL-10 in monocytes and dendritic cells. Because reciprocal inhibition exists between IL-10 and IL-12, we explored whether IgA could regulate this other immunoregulatory cytokine. In human monocytes and monocyte-derived dendritic cells preincubated with IFN-γ before stimulation by LPS, suppression of p40 and IL-12p70 production was observed upon IgA treatment during IFN-γ priming. Washout experiments and inhibition of IFN-γ-induced CXCL10 (IP-10) and FcgRI (CD64) indicated that inhibition by IgA occurred at both the LPS and IFN-γ levels. Inhibition was not affected by blockade of IL-10 or MAPK but involved FcaRI/CD89-mediated suppression of STAT1 phosphorylation. These data indicate that FcaRI ligation on human monocytes and dendritic cells inhibits IL-12 expression and type 1 activation by interfering with STAT1 activation. Copyright © 2013 by The American Association of Immunologists, Inc. All rights reserved.
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Lecocq, M., Detry, B., Guisset, A., & Pilette, C. (2013). FcαRI-mediated inhibition of IL-12 production and priming by IFN-γ of human monocytes and dendritic cells. Journal of Immunology, 190(5), 2362-2371. https://doi.org/10.4049/jimmunol.1201128 (Original work published 2013)