Opportunités et défis de la vaccination thérapeutique anti-tumorale.
(2007) Academie Royale de Medecine de Belgique. Bulletin et Memoires — Vol. 162, n° 10-12, p. 505-514 (2007)
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- Abstract
- Therapeutic anti-cancer vaccines containing tumor-specific antigens recognized by T lymphocytes are thought to stimulate high numbers of anti-vaccine cytolytic T lymphocytes (CTL) which then can lyse the tumor cells. To understand why these vaccines are followed by tumor regressions in only 10% of the patients, we analysed the tumor-specific immune responses of these patients. Contrary to our expectations, the anti-vaccine CTL responses were of very low level. However, regressing tumors were massively infiltrated by anti-tumor T cells of other specificities, including new anti-tumor CTL clonotypes that emerged following vaccination. We now believe that the role of the anti-vaccine CTL is to activate or restimulate large numbers of other anti-tumor CTL. Their ability to initiate this response is probably more important than their number. These results have important consequences for the improvement of the clinical efficacy of anti-cancer vaccines.
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Citations
Coulie, P. (2007). Opportunités et défis de la vaccination thérapeutique anti-tumorale. Academie Royale de Medecine de Belgique. Bulletin et Memoires, 162(10-12), 505-514. https://hdl.handle.net/2078.5/211763 (Original work published 2007)